Methods to Assess Longitudinal Data
Many biological and clinical questions of interest are temporal in nature. These include clinical studies whose goals are to assess the time of onset of different treatments, to observe the effect of drug treatment over time, and to monitor the long-term safety of therapeutics. In this article, we discuss several important considerations involved in the analysis of temporal and longitudinal data, specifically related to framing a question, designing a study, analyzing data, and interpreting results. We also refer to several recent, real-world examples of these topics.
